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November 20, 2025Frontiers in ImmunologyOpen Access

Identification and validation of mitochondrial and programmed cell death-related prognostic markers in pediatric acute myeloid leukemia

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Authors

XHXiaoyan HuQZQiang ZhaoWDWei Deng

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Overview

Analysis identifies programmed cell death and mitochondrial prognostic markers in pediatric AML, suggesting new therapeutic avenues.

Key Points

  • The study aims to identify prognostic markers associated with programmed cell death and mitochondrial function in pediatric acute myeloid leukemia.
  • Identified candidate genes using transcriptomic data and public gene sets.
  • Performed regression analyses to find prognostic genes and developed a prognostic model.
  • Constructed a nomogram and conducted functional analyses and immune microenvironment assessment.
  • Identified three key prognostic markers: PDHA1, OGG1, and OPA1.
  • Demonstrated the robustness of the prognostic model through validations.
  • Computed pathway enrichment highlighting DNA replication and immune cell involvement.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/6924f07ac0ce034ddc34fd21https://doi.org/10.3389/fimmu.2025.1671230
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  5. 5A novel mitochondrial function-associated programmed cell death-related prognostic signature for predicting the prognosis of early breast cancer2024 · 4 citations