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November 20, 2025Blood ScienceOpen Access

Cerebrospinal fluid profile associated with the incidence and outcomes of patients with chronic graft-versus-host disease after haploidentical hematopoietic stem cell transplantation

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Authors

CZChen ZhaoHFHai-Xia FuXMXiao-Dong Mo

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Overview

Retrospective case-control study establishes a nomogram for cumulative incidence of chronic graft-versus-host disease, highlighting risk factors and non-relapse mortality.

Key Points

  • To explore the relationship between cerebrospinal fluid profile and outcomes in chronic graft-versus-host disease after haploidentical hematopoietic stem cell transplantation.
  • Conducted a retrospective nested case-control study of patients who underwent haplo-HSCT.
  • Enrolled 87 patients with chronic graft-versus-host disease and tested their cerebrospinal fluid.
  • Identified acute GVHD, CSF proteins, and oligoclonal bands as risk factors for cGVHD onset.
  • Established a nomogram for the cumulative incidence of chronic graft-versus-host disease.
  • Significant difference in non-relapse mortality observed in cGVHD compared to control groups.
  • Multivariate analysis showed that underlying diseases and CSF proteins were associated with CNS-cGVHD occurrence.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/6924f07ac0ce034ddc34fd42https://doi.org/10.1097/bs9.0000000000000250
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proposal for Diagnostic Criteria for Manifestations of Chronic Graft-versus-Host Disease in the Central Nervous System2025
  2. 2Proposal for Diagnostic Criteria for Manifestations of Chronic Graft-versus-Host Disease in Peripheral Nervous System and Muscles2026
  3. 3Neurological manifestations of chronic graft versus host disease2025 · 5 citations
  4. 4Retrospective analysis of the incidence and outcome of late acute and chronic graft-versus-host disease—an analysis from transplant centers across Europe2024 · 16 citations
  5. 5Oral chronic graft-versus-host disease (cGVHD) as a potential clinical marker of the graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation: A prospective single-center study2025