RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression

Wei-Kang Sun; Mengyu Zhang; Ruilin Wang; Jie Yang; Ameena Tur Rasool; Renjie Luo; Xiangdong Liu; Peng Cao; Erguang Li

doi:10.1186/s13578-025-01495-7

November 20, 2025Cell & BioscienceOpen Access

RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression

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Key Points

To investigate how PTBP1 mediates HSV-1 attachment and infection through gene expression regulation.
Examined the role of RNA-binding protein PTBP1 in HSV-1 infection
Evaluated splicing regulation of the HS3ST3A1 and HS3ST3B1 genes
Assessed epithelial cell responses to HSV-1 infection
PTBP1 mediates HSV-1 infection by regulating heparan sulfate synthesis
Splicing regulation of HS3ST3A1 and HS3ST3B1 genes was confirmed
Findings suggest new therapeutic strategies targeting PTBP1 and heparan sulfate.

Implication

Research demonstrates RNA-binding protein PTBP1 regulates heparan sulfate gene expression, suggesting potential therapeutic strategies against HSV-1 infection.

Abstract

The results demonstrate that PTBP1 mediates HSV-1 infection of epithelial cells through splicing regulation of HS3ST3A1/HS3ST3B1. These studies provide a new area for novel therapeutic strategies through splicing regulation.

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Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/6924f07ac0ce034ddc34fe5c https://doi.org/10.1186/s13578-025-01495-7

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RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression

Key Points

Implication

Abstract

Discussion

Cite This Study

RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression

Key Points

Implication

Abstract

Discussion

Cite This Study

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