January 1, 1999Journal of VirologyOpen Access

Polypyrimidine Tract-Binding Protein Binds to the Leader RNA of Mouse Hepatitis Virus and Serves as a Regulator of Viral Transcription

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Population

Mouse hepatitis virus leader RNA, cellular extracts, and recombinant polypyrimidine tract-binding protein

Design

Preclinical

Authors

HLHsin‐Pai LiChang Gung University PHPeiyong HuangUniversity of Southern California SPSung-Min ParkUniversity of Southern California

Discussion

Member takes

Implication

PTB may serve as a host target in coronavirus transcription; human therapeutic relevance remains to be tested.

Structured PICO

Population

Mouse hepatitis virus (MHV) leader RNA, cellular extracts, and recombinant polypyrimidine tract-binding protein (PTB)

Intervention

UV cross-linking, immunoprecipitation, deletion analyses, and defective-interfering RNA reporter system

Outcome

Binding of PTB to MHV plus-strand leader RNA and its role in viral RNA synthesis

Identifies polypyrimidine tract-binding protein (PTB) as a critical cellular factor that binds to the MHV leader RNA and regulates viral transcription.

Cite This Study

Li et al. (1999) studied this question.

synapsesocial.com/papers/6a70f03135aa2c282ce2435a https://doi.org/10.1128/jvi.73.1.772-777.1999

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Polypyrimidine Tract-Binding Protein Binds to the Leader RNA of Mouse Hepatitis Virus and Serves as a Regulator of Viral Transcription

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Polypyrimidine Tract-Binding Protein Binds to the Leader RNA of Mouse Hepatitis Virus and Serves as a Regulator of Viral Transcription

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider