June 1, 2001Journal of VirologyOpen Access

Heterogeneous Nuclear Ribonucleoprotein A1 Binds to the 3′-Untranslated Region and Mediates Potential 5′-3′-End Cross Talks of Mouse Hepatitis Virus RNA

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Population

Mouse hepatitis virus (MHV) RNA and host cell proteins (hnRNP A1, PTB) in vitro

Comparison

Mutations affecting PTB binding to the negative… vs Wild-type MHV RNA

Design

Preclinical

Authors

PHPeiyong HuangUniversity of Southern California MLMichael M. C. LaiSouth Australia Pathology

Discussion

Member takes

Implication

No immediate clinical implications for coronavirus therapies; leaves open host factor targeting for future mechanistic studies.

Structured PICO

Population

Mouse hepatitis virus (MHV) RNA and host cell proteins (hnRNP A1, PTB) in vitro

Intervention

Mutations affecting PTB binding to the negative strand of the 3'-UTR

Comparator

Wild-type MHV RNA

Outcome

RNA transcription and replication activities, and formation of an RNP complexsurrogate

hnRNP A1 interacts with the 3'-UTR of MHV RNA and, together with PTB, mediates potential 5'-3' cross talks important for viral RNA replication and transcription.

Cite This Study

Huang et al. (2001) studied this question.

synapsesocial.com/papers/6a1feb78f35583189204af2a https://doi.org/10.1128/jvi.75.11.5009-5017.2001

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Heterogeneous Nuclear Ribonucleoprotein A1 Binds to the 3′-Untranslated Region and Mediates Potential 5′-3′-End Cross Talks of Mouse Hepatitis Virus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heterogeneous Nuclear Ribonucleoprotein A1 Binds to the 3′-Untranslated Region and Mediates Potential 5′-3′-End Cross Talks of Mouse Hepatitis Virus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider