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April 1, 1995Journal of VirologyOpen Access

Specific binding of host cellular proteins to multiple sites within the 3' end of mouse hepatitis virus genomic RNA

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Key result

Host cellular proteins specifically bind to two distinct sites within the 3' end of the mouse hepatitis virus genomic RNA, forming identical RNA-protein complexes in both infected and uninfected cells.

Authors

YWYu WangFirst Affiliated Hospital of Jiangxi Medical CollegeJLJulian L. LeibowitzTexas A&M Health Science Center

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Implication

Host-RNA binding occurs pre-infection; leaves open functional roles and antiviral targeting in coronaviruses.

PICO

P
Population
Mouse hepatitis virus (MHV) infection
E
Exposure / Comparator
MHV-JHM infection vs Mock infection (uninfected cells)
O
Primary Outcome
Specific binding of host cellular proteins to the 3' end of MHV genomic RNA

Cite This Study

Wang et al. (1995) studied Mouse hepatitis virus (MHV) infection. MHV-JHM infection vs. Mock infection (uninfected cells) was evaluated on Specific binding of host cellular proteins to the 3' end of MHV genomic RNA. Host cellular proteins specifically bind to two distinct sites within the 3' end of the mouse hepatitis virus genomic RNA, forming identical RNA-protein complexes in both infected and uninfected cells.

synapsesocial.com/papers/6a942e24a09a696dc39c4ef4https://doi.org/10.1128/jvi.69.4.2016-2023.1995
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Also Consider

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  5. 5Oxidation-reduction sensitive interaction of a cellular 50-kDa protein with an RNA hairpin in the 5' noncoding region of the poliovirus genome.1990 · 60 citations