Key result
Double-membrane vesicles in the cytoplasm of MHV-infected cells carry the viral RNA replication complex and are the site of viral RNA synthesis.
Population
Mouse hepatitis virus (MHV)-infected cells
Design
Preclinical
Authors
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Suggests DMVs as antiviral targets in coronaviruses; extends animal models but leaves open human translation.
Mouse hepatitis virus RNA replication complexes are integral membrane proteins that localize to and synthesize RNA at double-membrane vesicles in the cytoplasm of infected cells.
Gosert et al. (2002) studied Mouse hepatitis virus (MHV) infection. MHV infection (in vitro) was evaluated on Localization of MHV RNA replication complex. Double-membrane vesicles in the cytoplasm of MHV-infected cells carry the viral RNA replication complex and are the site of viral RNA synthesis.
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