Key result
Hepatitis C virus replication in Huh7.5 cells induced the formation of double membrane vesicles containing viral non-structural proteins, viral RNA, and the autophagic marker LC3-II.
Authors
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May implicate autophagy in HCV replication; leaves open in vivo relevance and therapeutic targeting.
Ferraris et al. (2010) studied Hepatitis C virus infection. Hepatitis C virus replication vs. Naive Huh7.5 cells was evaluated on Ultrastructural and biochemical changes in host cell membranes. Hepatitis C virus replication in Huh7.5 cells induced the formation of double membrane vesicles containing viral non-structural proteins, viral RNA, and the autophagic marker LC3-II.
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