December 1, 1993Journal of VirologyOpen Access

Three different cellular proteins bind to complementary sites on the 5'-end-positive and 3'-end-negative strands of mouse hepatitis virus RNA

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Population

Mouse hepatitis virus RNA and cellular proteins from uninfected cells (DBT, HeLa, COS cells)

Design

Preclinical

Authors

TFTetsuya FuruyaTokyo University of Agriculture and Technology MLMichael M. C. LaiChinese University of Hong Kong

Discussion

Member takes

Implication

May implicate host proteins in MHV replication; leaves open functional validation and therapeutic relevance.

Structured PICO

Population

Mouse hepatitis virus RNA and cellular proteins from uninfected cells (DBT, HeLa, COS cells)

Intervention

RNA-protein binding studies (gel-retardation assays, UV cross-linking)

Outcome

Identification of cellular proteins binding to viral RNA terminisurrogate

Cellular proteins of 55, 35, and 38 kDa bind to complementary sites near the ends of positive- and negative-strand mouse hepatitis virus RNAs, suggesting a role in viral RNA replication.

Cite This Study

Furuya et al. (1993) studied this question.

synapsesocial.com/papers/6a87f1a0d79ae02bd34de6e5 https://doi.org/10.1128/jvi.67.12.7215-7222.1993

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Three different cellular proteins bind to complementary sites on the 5'-end-positive and 3'-end-negative strands of mouse hepatitis virus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Three different cellular proteins bind to complementary sites on the 5'-end-positive and 3'-end-negative strands of mouse hepatitis virus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider