Key result
The conserved 98-nucleotide region of the HCV 3'-UTR forms stem-loop structures that specifically bind the cellular polypyrimidine tract-binding protein (PTB).
Population
Hepatitis C virus RNA genome and mammalian cell lines/human primary hepatocytes
Design
Preclinical
Authors
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PTB binding to HCV stem-loops may regulate replication; leaves open its role in persistence and as antiviral target.
The highly conserved 3'-UTR of HCV RNA forms specific stem-loop structures that bind the cellular protein PTB, which may regulate viral RNA synthesis or translation.
Ito et al. (1997) studied Hepatitis C virus. Site-directed mutagenesis and UV cross-linking was evaluated on Cellular protein binding to the 3'-UTR of HCV RNA. The conserved 98-nucleotide region of the HCV 3'-UTR forms stem-loop structures that specifically bind the cellular polypyrimidine tract-binding protein (PTB).
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