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October 1, 1995Journal of VirologyOpen Access

Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation

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Key result

Polypyrimidine tract-binding protein (PTB) interacts with three distinct regions of the HCV 5' noncoding region and is functionally required for internal initiation of translation.

Population

Hepatitis C virus (HCV) RNA genome (5' noncoding region) and HeLa nuclear extracts

Design

Preclinical

Authors

NANaushad AliVeterans Health AdministrationASAleem SiddiquiUniversity of California, San Diego

Discussion

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Implication

Hypothesis-generating for PTB-targeted HCV antivirals; leaves open therapeutic relevance pending functional validation.

Structured PICO

P
Population
Hepatitis C virus (HCV) RNA genome (5' noncoding region) and HeLa nuclear extracts
I
Intervention
Polypyrimidine tract-binding protein (PTB) interaction and immunodepletion
O
Outcome
Interaction of PTB with the HCV 5'NCR and its functional requirement in translation initiationsurrogate

PTB interacts with multiple sites on the HCV 5'NCR and is functionally required, along with associated factors, for internal initiation of translation.

Cite This Study

Ali et al. (1995) studied Hepatitis C virus (HCV). Polypyrimidine tract-binding protein (PTB) was evaluated on Interaction with HCV 5'NCR and translation initiation. Polypyrimidine tract-binding protein (PTB) interacts with three distinct regions of the HCV 5' noncoding region and is functionally required for internal initiation of translation.

synapsesocial.com/papers/6a6c8be726a7f98052db42a7https://doi.org/10.1128/jvi.69.10.6367-6375.1995
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA1994 · 144 citations
  2. 2The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region1994 · 129 citations
  3. 3Cell type-specific proteins which interact with the 5' nontranslated region of hepatitis A virus RNA1993 · 65 citations
  4. 4Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions1994 · 41 citations
  5. 5Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.1992 · 161 citations