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October 1, 1977The Journal of BiochemistryOpen Access

Polyadenylate in the Virion RNA of Mouse Hepatitis Virus

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Population

Mouse hepatitis (MH) virus grown in SR-CDF1-DBT, a mouse cell line

Design

Preclinical

Authors

YYYoshiaki YogoTokyo Medical and Dental UniversityNHNorio HiranoTokyo University of AgricultureSHShigeo HinoNational Institutes of Health

Discussion

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Implication

No immediate clinical implications from this animal study; leaves open functional role in human coronaviruses.

Structured PICO

P
Population
Mouse hepatitis (MH) virus grown in SR-CDF1-DBT, a mouse cell line
I
Intervention
RNA extraction and analysis (ribonuclease A and T1 digestion, DEAE-Sephadex column chromatography, gel electrophoresis)
O
Outcome
Presence and characteristics of poly(A) in virion RNAsurrogate

Demonstrates that Mouse Hepatitis Virus virion RNA contains a polyadenylate sequence of approximately 90 nucleotides.

Cite This Study

Yogo et al. (1977) studied this question.

synapsesocial.com/papers/6a90ff6a073a0b1e9f744e85https://doi.org/10.1093/oxfordjournals.jbchem.a131782
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RNA Replication of Mouse Hepatitis Virus Takes Place at Double-Membrane Vesicles2002 · 447 citations
  2. 2Translation and processing of mouse hepatitis virus virion RNA in a cell-free system1986 · 87 citations
  3. 3Specific binding of host cellular proteins to multiple sites within the 3' end of mouse hepatitis virus genomic RNA1995 · 66 citations
  4. 4Characterization of Murine Coronavirus RNA by Hybridization with Virus-specific cDNA Probes1983 · 24 citations
  5. 5High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA2000 · 138 citations