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November 20, 2025npj MicrogravityOpen Access

Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

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Authors

DBDamian M. BaileyDBDieter BlottnerHGHanns‐Christian Gunga

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Overview

This review highlights health risks and discusses countermeasures for deep-space exploration, indicating the need for risk stratification.

Key Points

  • To understand the interaction between the space exposome and integrome and its impact on astronaut health.
  • Review of current literature and ESA community expertise on space exploration risks.
  • Analysis of physiological challenges faced by astronauts during missions beyond low Earth orbit.
  • Identified over thirty health risks linked to human spaceflight.
  • Outlined potential countermeasures to mitigate risks associated with altered gravity and cosmic radiation.

Cite This Study

Bailey et al. (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc3500ebhttps://doi.org/10.1038/s41526-025-00537-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Space physiology: Challenges and solutions for a journey to Mars2026
  2. 2Journeying beyond the gravity and interstellar space: Unveiling the Health Challenge in space missions – An extensive review2025
  3. 3Radiation risk mitigation in human space exploration: a primer, a vision, and the state of the art2026
  4. 4Space Medicine: Challenges for Deep Space Exploration2025
  5. 5Cardiovascular risks and hazards associated with deep space exploration2026