What question did this study set out to answer?

To identify novel susceptibility loci for high-grade serous ovarian cancer (HGSOC) using a genome-wide association study (GWAS).

November 20, 2025npj Genomic MedicineOpen Access

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer

View Full Paper

Ask AI

Bookmark

Authors

Genome-wide association study reveals TP53 and polygenic scores linked to HGSOC risk in 398,238 women, suggesting improved prediction strategies.

To identify novel susceptibility loci for high-grade serous ovarian cancer (HGSOC) using a genome-wide association study (GWAS).
Meta-analysis of over 22 million variants across a cohort of 398,238 women from multiple consortia
Assessment of risk associated with TP53 SNP rs78378222-T
Development of polygenic scores using data from the Ovarian Cancer Association Consortium and FinnGen.
Identified eight novel variants linked to HGSOC risk
TP53 3'-UTR SNP's association with HGSOC showed a relative risk of 1.44
The optimal polygenic score was related to an odds ratio of 1.46 when validated.

Barnes et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Genome-wide association study reveals TP53 and polygenic scores linked to HGSOC risk in 398,238 women, suggesting improved prediction strategies.