What question did this study set out to answer?

To investigate the mechanisms by which Th17 cells and IL-17A contribute to autoimmune and inflammatory neurological diseases.

November 20, 2025Frontiers in ImmunologyOpen Access

The critical role of Th17 cells and IL-17A in autoimmune and inflammation-associated neurological diseases: mechanisms and therapeutic perspectives

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This review highlights the role of Th17 cells and IL-17A in neuroinflammation and autoimmune diseases, suggesting new therapeutic strategies.

To investigate the mechanisms by which Th17 cells and IL-17A contribute to autoimmune and inflammatory neurological diseases.
Reviewed molecular mechanisms regulating Th17 differentiation and function.
Analyzed the interplay between cytokines and transcription factors in Th17 cell activity.
Discussed emerging therapies targeting Th17/Treg balance.
Th17 cells are linked to neuroinflammation in diseases like multiple sclerosis and Alzheimer's.
Cytokines such as IL-6 and IL-23 play critical roles in Th17 cell differentiation.
Therapeutics like anti-IL-17 monoclonal antibodies may mitigate Th17-associated damage.

Lou et al. (2025) studied this question.

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This review highlights the role of Th17 cells and IL-17A in neuroinflammation and autoimmune diseases, suggesting new therapeutic strategies.