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November 20, 2025BiomoleculesOpen Access

Sequence Determinants of G-Quadruplex Thermostability: Aligning Evidence from High-Precision Biophysics and High-Throughput Genomics

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Authors

KXKe XiaoJFJiye FuRZRongxin Zhang

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Overview

This review demonstrates how G-quadruplexes' thermostability is influenced by sequence features in health and disease, highlighting biophysical findings.

Key Points

  • This review aims to synthesize evidence on the sequence determinants of G-quadruplex thermostability.
  • Systematic review of high-precision biophysical studies
  • Integration of high-throughput genomic assays
  • Analysis of G-tract core, loops, and flanking sequences
  • Identified key sequence features influencing G-quadruplex stability
  • Established a link between structural elements and thermostability
  • Demonstrated an inverse relationship between loop length and stability

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/6924f08cc0ce034ddc3506c3https://doi.org/10.3390/biom15111632
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stability Matters: Revealing Causal Roles of G-Quadruplexes (G4s) in Regulation of Chromatin and Transcription2025
  2. 2Large-Scale Conformational Analysis Explains G-Quadruplex Topological Landscape2025
  3. 3Can intrinsic loop energetics predict G-Quadruplex topology?2026
  4. 4G-Quadruplex Unwinding Molecular Mechanisms by Helicases and Their Applications2026 · 3 citations
  5. 5Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences2025