Exposure‐Response Analysis for Time‐to‐Event Data in the Presence of Adaptive Dosing: Efficient Approaches and Pitfalls

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This analysis compares timepoint metrics and power in assessing exposure-response relationships for adaptive dosing.

Adaptive dosing approaches may improve power in analyzing exposure-response relationships, enabling more accurate outcomes.
Key findings show that timepoint metrics impact power significantly when evaluating time-to-event responses with exposure variations.
Simulation study utilized time-dependent models to investigate exposure-response dynamics across varied dosing scenarios and events.
Results highlight the importance of using appropriate timepoint assessments to ensure statistical reliability in clinical settings.

Lavalley‐Morelle et al. (2025) studied this question.

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