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November 19, 2025Journal of Orthopaedic Surgery and ResearchOpen Access

The effect of pulsatile lavage on antibiotic elution from bone cements in two-stage revision for periprosthetic joint infection

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Authors

KKKevin KnappeMSMareike SchonhoffTBTherese Bormann

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Implication

This study demonstrates altered antibiotic release in bone cements for periprosthetic joint infection, suggesting pulsatile lavage has minimal impact on gentamicin elution.

Key Points

  • To investigate how pulsatile lavage affects antibiotic elution from bone cements used in two-stage revision for periprosthetic joint infection.
  • Three PMMA bone cements prepared with gentamicin and vancomycin were tested.
  • Cement blocks underwent either non-lavage or high-pressure pulsatile lavage before being tested in a buffer solution.
  • Antibiotic release was analyzed at ten time points over six weeks.
  • Significant differences in gentamicin release kinetics observed for bone cement A and B post-lavage.
  • Cumulative vancomycin release significantly reduced in Group B post-lavage with p < 0.001.
  • Overall impact of lavage on antibiotic elution was minimal across the different cements.

Cite This Study

Knappe et al. (2025) studied this question.

synapsesocial.com/papers/6924f095c0ce034ddc350ad8https://doi.org/10.1186/s13018-025-06454-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of surface structuring on antibiotic elution from bone cement in two-stage revision for periprosthetic joint infection2026
  2. 2Vancomycin elution and antibacterial activity of medium-viscosity versus medium-high-viscosity antibiotic-loaded bone cement: an in vitro comparative study2026
  3. 3High and Low Dosage of Vancomycin in Polymethylmethacrylate Cements: Efficacy and Mechanical Properties2024 · 16 citations
  4. 4Clinical Efficacy and Safety of Multiple High-Dose Antibiotic-Loaded Cement Spacers in the Two-Stage Revision of Gram-Positive Periprosthetic Joint Infection2026 · 1 citations
  5. 5Effect of Multiantibiotic-Loaded Bone Cement on the Treatment of Periprosthetic Joint Infections of Hip and Knee Arthroplasties—A Single-Center Retrospective Study2024 · 7 citations