What type of study is this?

This is a Animal Study study (also classified as: In Vitro Study).

What question did this study set out to answer?

The study aims to elucidate the mechanisms of corylin's effects on osteoporosis through network pharmacology and molecular docking.

November 19, 2025Scientific ReportsOpen Access

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In vitro experiments show therapeutic targets of corylin improve osteoporosis by modulating the MAPK pathway.

The study aims to elucidate the mechanisms of corylin's effects on osteoporosis through network pharmacology and molecular docking.
Identified 213 potential therapeutic targets and 44 key targets related to osteoporosis.
Screened top 10 hub genes using CytoHubba, including MMP9, BCL2, and others.
Conducted transcriptomic analysis to validate MAPK pathway involvement and performed in vitro experiments with corylin.
Corylin significantly impaired cell proliferation and induced apoptosis in vitro.
Reduced levels of P-MEK1/2, ATF1, and increased apoptosis markers observed through Western blot.
Corylin treatment improved bone microarchitecture and modulated serum markers in an osteoporosis model.

Liu et al. (2025) studied this question.

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