SIRT5 affects lipid accumulation in cells of a metabolic-associated fatty liver disease model by regulating the succinylation status of HSPD1

Yuan-Xing Lu; Qi Peng; Beizhong Liu; Bo Xie

doi:10.1186/s12865-025-00776-7

November 19, 2025BMC ImmunologyOpen Access

SIRT5 affects lipid accumulation in cells of a metabolic-associated fatty liver disease model by regulating the succinylation status of HSPD1

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Key Points

This research aims to explore the role of SIRT5 in regulating lipid accumulation and its impact on hepatic steatosis in MAFLD model cells.
Used a metabolic-associated fatty liver disease model
Analyzed the succinylation status of HSPD1
Investigated the effects of SIRT5-mediated desuccinylation
SIRT5 regulates lipid accumulation in liver cells
Desuccinylation of HSPD1 protects against hepatic steatosis
Targeting SIRT5 and HSPD1 may be a novel therapeutic strategy for MAFLD

Implication

SIRT5 impacts lipid accumulation and hepatic steatosis in MAFLD, indicating a potential therapeutic strategy.

Abstract

SIRT5-mediated desuccinylation of HSPD1 protects against hepatic steatosis in MAFLD model cells, suggesting that targeting SIRT5 and HSPD1 may represent a novel therapeutic strategy for preventing and treating MAFLD.

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Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/6924f095c0ce034ddc350b99 https://doi.org/10.1186/s12865-025-00776-7

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SIRT5 affects lipid accumulation in cells of a metabolic-associated fatty liver disease model by regulating the succinylation status of HSPD1

Key Points

Implication

Abstract

Discussion

Cite This Study

SIRT5 affects lipid accumulation in cells of a metabolic-associated fatty liver disease model by regulating the succinylation status of HSPD1

Key Points

Implication

Abstract

Discussion

Cite This Study

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