Key result
Adolescent stage 2 hypertension is linked to ~84% higher risk of severe middle-age coronary stenosis.
Why the study?
Does elevated blood pressure in adolescence increase the risk of coronary atherosclerosis in middle age?
Population
10,222 men with a mean age of 18.3 years at baseline from the Swedish Military Conscription Register.
Comparison
Elevated blood pressure in adolescence… vs Normal blood pressure in adolescence.
Design
Cohort
Follow-up
median 39.5 (35.2-42.8) years
Authors
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Elevated blood pressure during adolescence is associated with a dose-dependent increased risk of developing severe coronary atherosclerosis by middle age.
Cohort (n=10,222)
Does elevated blood pressure in adolescence increase the risk of coronary atherosclerosis in middle age?
Odds Ratio: 1.84 (95% CI 1.4–2.42)
Absolute Event Rate: 10.1% vs 6.9%
Elevated blood pressure during adolescence is associated with a dose-dependent increased risk of developing severe coronary atherosclerosis by middle age.
Adillo et al. (2025) conducted a cohort in Elevated blood pressure (n=10,222). Elevated blood pressure in adolescence (stage 2 hypertension) vs. Normal blood pressure was evaluated on Coronary atherosclerosis, evaluated via CCTA stenosis (OR 1.84, 95% CI 1.40-2.42). Adolescent stage 2 hypertension was associated with a higher risk of severe coronary stenosis (≥50%) in middle age compared to normal blood pressure (OR 1.84; 95% CI 1.40-2.42).
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