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November 19, 2025PharmaceuticsOpen Access

Design of Peptide-Modified Aluminum Nanoparticles with Enhanced Antimicrobial, Antibiofilm, Antioxidant, and DNA-Cleaving Properties

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Authors

ZKZeynep KanlıdereNÖNazlı Farajzadeh ÖztürkMYM. Serkan Yalçın

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Overview

Peptide-conjugated nanoparticles show improved antimicrobial activity in vitro, suggesting potential against resistant bacteria.

Key Points

  • The research aims to evaluate the biological effects of peptide-modified aluminum nanoparticles on antimicrobial and antioxidant activities.
  • Peptide conjugation performed on aluminum nanoparticles to create NP1–NP3.
  • Antimicrobial activity tested against bacterial strains including S. aureus and P. aeruginosa.
  • Assays conducted for biofilm inhibition, microbial cell viability, antioxidant activity, and DNA cleavage.
  • Peptide-conjugated nanoparticles exhibited significant antimicrobial activity with MIC values of 16 mg/L.
  • NP2 showed the highest biofilm inhibition rates of 53% against S. aureus and 70% against P. aeruginosa.
  • NP1–NP3 inhibited microbial cell viability by 100% at concentrations of 6.25 mg/L.

Cite This Study

Kanlıdere et al. (2025) studied this question.

synapsesocial.com/papers/6924fed1c0ce034ddc350dd4https://doi.org/10.3390/pharmaceutics17111490
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