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November 19, 2025Scientific ReportsOpen Access

Exploring the role of hepatic lipid droplets in mouse liver toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: sequestration, biochemical alterations and gene regulation

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Authors

NHNour HammoudehCSChadi SoukkariehAHAbdulsamie Hanano

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Overview

This study demonstrates biochemical alterations and gene regulation linked to liver toxicity in mice exposed to dioxin, indicating a need for detoxification strategies.

Key Points

  • This research aims to explore how hepatic lipid droplets are affected by dioxin toxicity in mouse liver.
  • Female and male BALB/c mice were administered TCDD orally at varying doses.
  • Liver weight and lipid droplet changes were evaluated post-exposure.
  • HPLC analysis was conducted to assess TCDD accumulation and storage in liver lipid droplets.
  • Gene expression for hepatotoxicity and lipid formation markers was analyzed.
  • TCDD exposure led to a dose-dependent increase in liver weight, indicating hepatomegaly.
  • The quantity and protein composition of hepatic lipid droplets increased with TCDD exposure.
  • Enhanced hydroxylation enzymatic activity was observed in male mice.
  • Significant alterations were noted in gene expression related to hepatotoxicity markers and lipid droplet formation.

Cite This Study

Hammoudeh et al. (2025) studied this question.

synapsesocial.com/papers/6924fed1c0ce034ddc350eb9https://doi.org/10.1038/s41598-025-21508-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subchronic low dose dioxin exposure disrupts hepatic and metabolic homeostasis in a sex- and diet-dependent manner2026
  2. 2Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure2024 · 2 citations
  3. 3Assessment of The toxic Effect of Environmental Pollution by 2 ,3 ,7 ,8 - Tetrachlorodibenzo-p-dioxin (TCDD) on The Female Reproductive System by Pathological and Biochemical Assay in Albino Female Rats2024 · 4 citations
  4. 4Transcriptomic analysis of AHR wildtype and Knock-out rat livers supports TCDD's role in AHR/ARNT-mediated circadian disruption and hepatotoxicity2024 · 2 citations
  5. 5Investigating the mode of action for wasting produced by tetrachlorodibenzo-p-dioxin (TCDD) in rats using transcriptomics: Evidence for roles of AHR and ARNT in circadian cycling2024 · 2 citations