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June 20, 2026Current Research in ToxicologyOpen Access

Subchronic low dose dioxin exposure disrupts hepatic and metabolic homeostasis in a sex- and diet-dependent manner

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Authors

OBOluwanifemi E. BolatimiYHYuan HuaGPG. J. Phillips

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Overview

Randomized trial investigates liver damage effects of low-dose dioxin exposure in mice, suggesting sex and diet influence toxicity.

Key Points

  • This research aims to understand how low-dose dioxin exposure affects liver health and metabolism differently in male and female mice based on diet.
  • C57BL/6 J mice were assigned to low-fat diet (LFD) or high-fat diet (HFD) with weekly dioxin mixture exposure (TCDD, PeCDF, PCB126) for 12 weeks.
  • Liver samples were collected for analysis after exposure to evaluate metabolic effects and gene expression.
  • Measurement of liver weight, triglycerides, alanine aminotransferase levels, and gene expression was conducted.
  • LFD-fed females showed reduced liver weight and elevated triglycerides, while LFD-fed males exhibited impaired glucose tolerance.
  • Both sexes activated aryl hydrocarbon receptor (AHR) signaling, but HFD diminished this effect in males.
  • Only LFD-fed males experienced gene activation associated with constitutive androstane receptor (CAR).

Cite This Study

Bolatimi et al. (2026) studied this question.

synapsesocial.com/papers/6a363123db0793dc1a53818fhttps://doi.org/10.1016/j.crtox.2026.100311
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