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September 10, 2025Archives of ToxicologyOpen Access

Long-term TCDD oral exposure changes gut microbial glycosylation patterns in female but not male C57BL/6 mice

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Authors

DRDoreen ReichertSJStefan JanssenARAndrea Rossi

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Overview

Long-term TCDD exposure affects gut microbial glycosylation in female mice, suggesting sex-specific dysbiosis.

Key Points

  • Significant changes in gut microbial glycosylation patterns were observed in TCDD-treated female mice.
  • 16S sequencing revealed increased α-diversity and significant microbiota composition differences between male and female C57BL/6 mice.
  • Flow cytometry identified distinct microbial signatures in TCDD-exposed females, linking to potential glycosylation changes.
  • The study highlights the importance of assessing sex differences in glycosylation related to gut microbiota dysbiosis.

Cite This Study

Reichert et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec370https://doi.org/10.1007/s00204-025-04137-6
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