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November 14, 2025Scientific ReportsOpen Access

Sex-dependent modulation of PCB-mediated toxicity from a proteomic and microbiome perspective

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Authors

RSRicha SinghalZQZayna QaissiHZHao Zheng

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Overview

This research demonstrates distinct PCB responses in hepatic proteome and gut microbiome of C57BL/6J mice, indicating sex-dependent toxicity effects.

Key Points

  • The study investigates sex-dependent mechanisms of PCB toxicity through proteomic and microbiome analysis.
  • Male and female C57BL/6J mice were exposed to Aroclor1260 and PCB126 via oral gavage.
  • Peptide measurements were done using LC/MS on hepatic tissues.
  • Gut microbiome composition was analyzed using 16S sequencing.
  • PCB-exposed females showed increased CD36 and AHR activity in the hepatic proteome compared to males.
  • Males exhibited higher Dehalobacterium abundance and altered expression of gut barrier genes after PCB exposure.
  • Overall, sex influenced both hepatic and gut microbiome responses to PCB exposure.

Cite This Study

Singhal et al. (2025) studied this question.

synapsesocial.com/papers/692519a2c0ce034ddc353ca3https://doi.org/10.1038/s41598-025-23603-w
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  5. 5Subchronic low dose dioxin exposure disrupts hepatic and metabolic homeostasis in a sex- and diet-dependent manner2026