Mechanistic analysis reveals that ubiquitination of histones differently impacts chromatin regulation, indicating their complex roles in transcription.
Our findings quantitatively explain how H2A and H2B ubiquitination exert opposing effects on chromatin regulation. This mechanism is directly relevant to the opposing roles of these marks in transcriptional activation and repression, and may represent one way that combinations of histone modifications modulate chromatin function in vivo.
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Baweja et al. (2025) studied this question.
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