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The review addresses the challenge of immunogenicity associated with AAV in gene therapy.

November 19, 2025PharmaceuticsOpen Access

Emerging Technologies Tackling Adeno-Associated Viruses (AAV) Immunogenicity in Gene Therapy Applications

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Review highlights strategies to overcome AAV immunogenicity in gene therapy targeting severe diseases like spinal muscular atrophy.

The review addresses the challenge of immunogenicity associated with AAV in gene therapy.
Evaluation of existing approaches to overcome immunity against AAV
Discussion of capsid modifications and codon optimization
Consideration of pharmacological supports like immunosuppressive corticosteroids and nanoparticles
Identified critical factors influencing AAV immunogenicity
Outlined potential strategies for effective gene therapy re-administration
Highlighted the role of memory T cells and antibodies in treatment efficacy

Egorova et al. (2025) studied this question.

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