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November 19, 2025BMC Research NotesOpen Access

The influence of dopamine receptor SNPs on substance use disorder in a Jordanian cohort

Ola AL-Sanabra Laith AL-Eitan Maryam Alasmar

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Key Points

To examine the association of dopamine receptor SNPs with substance use disorder in a Jordanian cohort.
Analyzed SNPs rs686 and rs6280 for association with substance use disorder.
Conducted genotypic and allelic frequency analyses of dopamine receptor genes.
Used multinomial logistic regression to assess relationships with smoking and marital status.
Significant association found between rs686 SNP and substance use disorder onset.
GG genotype was significantly linked to substance use disorder.
Genetic risk factors include CG haplotype of DRD1 and ACG haplotype of DRD4.

Implication

Observations reveal significant links between genetic factors and substance use disorder, suggesting implications for prevention.

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Cite This Study

AL-Sanabra et al. (2025) studied this question.

synapsesocial.com/papers/6924fed1c0ce034ddc350f6d https://doi.org/10.1186/s13104-025-07523-6

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