Inhibition of protease-activated receptor-2 attenuates multi-walled carbon nanotube exacerbation of allergic lung disease in mice

Inhibition of canonical PAR2 signaling using SAM-11 attenuates multiple features of MWCNT-enhanced allergic lung disease with broader efficacy than PAR2-deficient models. These findings highlight PAR2 as a viable therapeutic target in allergic lung disease and asthma, suggesting that antibody-based blockade is a promising strategy for mitigating allergen and particle-induced disease.