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Cobalt-catalyzed cross-coupling achieves C(sp3)–S bond formation, suggesting a sustainable alternative to costly oxidants.
Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp3)-H bond formation with N-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp3)–S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C–H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C–S bond formation.
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Qin et al. (2025) studied this question.
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