Experimental study demonstrates cobalt-catalyzed carbonylation of aliphatic amides into succinimides using solid molybdenum hexacarbonyl, highlighting a safer synthetic route.
The carbonylation of unactivated C(sp 3 )H bonds represents an attractive strategy for the synthesis of valuable carbonyl‐containing compounds. Herein, we report a cobalt‐catalyzed 8‐aminoquinoline‐directed carbonylative C(sp 3 )H cyclization of aliphatic amides using Mo(CO) 6 as a practical solid CO surrogate. This atom‐economical protocol provides straightforward access to substituted succinimides in good‐to‐excellent yields, employing low cobalt catalyst loadings (5 mol%). The reaction proceeds under operationally simple conditions and avoids the direct handling of gaseous carbon monoxide. To the best of our knowledge, this study represents the first example of a cobalt‐catalyzed C(sp 3 )H carbonylative transformation using Mo(CO) 6 as the carbon monoxide source.
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Duro et al. (2026) studied this question.
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