Protocol demonstrates exceptional scalability in amination of benzylic C(sp 3 )─H bonds, suggesting broad applications for drug-like molecules.
We present an environmentally benign and efficient strategy for the direct amination of benzylic C(sp 3 )─H bonds. This method operates under metal‐free, photocatalyst‐free, and oxidant‐free conditions. Notably, the protocol demonstrates exceptional functional group tolerance and scalability, enabling gram‐scale synthesis and late‐stage functionalization of complex drug‐like molecules.
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Zhang et al. (2025) studied this question.
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