Analysis highlights doxycycline's role in preventing sexually transmitted infections, suggesting a need for increased surveillance of Mycoplasma genitalium.
In the August issue of Sexual Health, a public health ethics analysis for and against doxycycline pre-exposure prophylaxis (Doxy-PEP) to prevent sexually transmitted infections in men who have sex with men was published. The authors discuss the potential for increasing antimicrobial resistance with Doxy-PEP use against tetracyclines in a number of pathogens. Mycoplasma genitalium is a commensal organism that is prone to developing antibiotic resistance due to a number of factors. As doxycycline is the backbone for the treatment of M. genitalium infections, antimicrobial resistance surveillance in M. genitalium needs to be prioritized as Doxy-PEP becomes increasingly used as a strategy to prevent sexually transmitted infections.
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Jeffrey D. Jenks (2025) studied this question.
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