DHEA supplementation improves cardiac functions in aged rats, suggesting a therapeutic value in reducing inflammation and enhancing Sirt1 and Nrf2 activity.
DHEA supplementation in aged rats mitigated cardiovascular aging by improving hemodynamic parameters, reducing myocardial injury, demoting inflammation, enhancing antioxidant capacity, and activating key protective genes. Our findings support a potential therapeutic value of DHEA in modulating age-dependent decline in cardiac functions through a possible NFκB/IL-10/Sirt1/Nrf2 pathway.
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Naguib et al. (2025) studied this question.
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