Key result
Two weeks of estrogen or raloxifene treatment enhanced antioxidant defense mechanisms and attenuated cardiac remodeling related to aging in female Wistar rats.
Why the study?
HRT decreases cardiovascular risks and events in postmenopausal women, but its effects are not fully elucidated in older individuals.
Does hormone replacement therapy (estrogen or raloxifene) improve oxidant/antioxidant homeostasis and cardiac remodeling in aging female rats?
Does hormone replacement therapy (estrogen or raloxifene) improve oxidant/antioxidant homeostasis and cardiac remodeling in aging female rats?
Short-term hormone replacement therapy with estrogen or raloxifene attenuates age-related cardiac remodeling and oxidative damage in a rat model.
HRT may mitigate age-related cardiac oxidative stress and remodeling in rats; leaves open translation to older postmenopausal women.
Advanced age is an independent risk factor for cardiovascular diseases, which might be further exacerbated by estrogen deficiency. Hormone replacement therapy (HRT) decreases cardiovascular risks and events in postmenopausal women; however, its effects are not fully elucidated in older individuals. Thus, the aim of our study is to examine the impact of HRT on oxidant/antioxidant homeostasis and cardiac remodeling. In our experiment, control (fertile) and aging (~20‐month‐old) female Wistar rats were used. Aging rats were further divided into estrogen‐ (E 2 , 0.1 mg/kg/day per os ) or raloxifene‐ (RAL, 1.0 mg/kg/day per os ) treated subgroups. After 2 weeks of treatment, cardiac heme oxygenase (HO) activity, total glutathione (GSH) content, matrix metalloproteinase‐2 (MMP‐2) activity, and the concentrations of collagen type I and tissue inhibitor of metalloproteinase (TIMP‐2), as well as the infarct size, were determined. The aging process significantly decreased the antioxidant HO activity and GSH content, altered the MMP‐2/TIMP‐2 signaling, and resulted in an excessive collagen accumulation, which culminated in cardiovascular injury. However, 2 weeks of either E 2 or RAL treatment enhanced the antioxidant defense mechanisms and attenuated cardiac remodeling related to aging. Our findings clearly show that 2‐week‐long HRT is a potential intervention to bias successful cardiovascular aging via reducing oxidative damage and cardiovascular dysfunction.
No takes yet. Share an insight, caveat, or question.
Szabó et al. (2021) studied Age-related oxidative stress and cardiac remodeling. Estrogen (E2) or raloxifene (RAL) vs. Control (fertile) and untreated aging rats was evaluated on Cardiac heme oxygenase (HO) activity, total glutathione (GSH) content, matrix metalloproteinase-2 (MMP-2) activity, collagen type I, TIMP-2, and infarct size. Two weeks of estrogen or raloxifene treatment enhanced antioxidant defense mechanisms and attenuated cardiac remodeling related to aging in female Wistar rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: