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March 1, 2016Clinical Interventions in AgingOpen Access

Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress

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Population

Female Wistar rats (3 or 22 months old)

Comparison

Ovariectomy (bilateral ovaries removal) and aging vs Young controls, young ovariectomized, and old…

Design

Preclinical

Follow-up

9 weeks

Authors

JMJacqueline Freire MachiDDDanielle da Silva DiasSFSarah Cristina Ferreira Freitas

Discussion

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Overview

Aging and OVX interactions on rat cardiac parameters are hypothesis-generating; human studies needed before clinical relevance.

Structured PICO

P
Population
Female Wistar rats (3 or 22 months old)
I
Intervention
Ovariectomy (bilateral ovaries removal) and aging
C
Comparator
Young controls, young ovariectomized, and old controls
O
Outcome
Metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameterssurrogate

In a female rat model, ovariectomy exacerbated age-related cardiac and functional impairments, likely driven by autonomic dysfunction, inflammation, and oxidative stress.

Cite This Study

Machi et al. (2016) studied this question.

synapsesocial.com/papers/6a6fa0788031ec7bb1dbdaeahttps://doi.org/10.2147/cia.s88441
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