Key result
Ovariectomy induces cardiomyopathic changes and elevates oxidative stress markers versus healthy controls.
RCT (n=12)
randomly allocated
Ovariectomy in rats leads to cardiomyopathic changes mediated by oxidative stress, providing a potential pathophysiological basis for postmenopausal cardiovascular risk.
Hypothesis-generating for oxidative stress in estrogen-deficient cardiomyopathy; human studies needed before clinical relevance.
OBJECTIVES: Menopause has a negative effect on cardiovascular functions. However, very little is known of the overall effect of menopause on the cardiac ultrastructure or the pathophysiological basis of this. METHODS: A group of 12-week-old female Sprague Dawley rats were randomly allocated to healthy control (n = 6) and ovariectomy groups (n = 6). Twelve weeks after ovariectomy, the rats' cardiac tissues were histopathologically analyzed for determination of oxidant and antioxidant enzymes [activities of catalase (CAT), superoxide dismutase (SOD), and myeloperoxidase (MPO) and amount of glutathione (GSH) and lipid peroxidation (LPO)]. RESULTS: When compared to the control group, the ovariectomy group showed cardiomyopathic changes. In tissue, activities of CAT (185 ± 2.4 vs. 112 ± 1.4 mmol/min/mg tissue; p < 0.05), SOD (153 ± 1.0 vs. 146 ± 0.7 mmol/min/mg tissue; p < 0.05) and MPO (19 ± 0.8 vs. 8.6 ± 0.11 μmol/min/mg tissue; p < 0.05) and LPO levels (32.1 ± 0.77 vs. 14.4 ± 0.20 nmol/g tissue; p < 0.05) were significantly increased in the ovariectomy group when compared to the control group. However, GSH levels (3.43 ± 0.02 vs. 3.73 ± 0.01 nmol/g tissue; p < 0.05) were significantly lower in the ovariectomy group when compared to the control group. CONCLUSION: Using an experimental animal model, we were able to demonstrate that menopause causes cardiomyopathic changes, and we propose that these changes could be mediated by oxidative stress.
No takes yet. Share an insight, caveat, or question.
Aksakal et al. (2011) conducted an RCT in Menopause-induced cardiomyopathic changes (n=12). Ovariectomy vs. Healthy control was evaluated on Cardiomyopathic changes and oxidant/antioxidant enzyme levels (p=<0.05). Ovariectomy induced cardiomyopathic changes and significantly increased oxidative stress markers including CAT, SOD, MPO, and LPO compared to healthy controls (p < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
More on CardiomyopathyMore from Cardiology