January 1, 2006Gynecological Endocrinology
Ovariectomy exacerbates oxidative stress and cardiopathyinduced by adriamycin
Why the study?
Does ovariectomy exacerbate oxidative stress and cardiopathy induced by adriamycin in experimental animals?
Population
Experimental animals (model of oxidative stress and cardiopathy induced by adriamycin)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open whether menopause exacerbates anthracycline cardiotoxicity.
Structured PICO
Does ovariectomy exacerbate oxidative stress and cardiopathy induced by adriamycin in experimental animals?
P
Population
Experimental animals (model of oxidative stress and cardiopathy induced by adriamycin)
I
Intervention
Ovariectomy (OVX)
O
Outcome
Cardiac damage markers (creatinine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase) and oxidative stress markers (malondialdehyde, catalase, superoxide dismutase, glutathione peroxidase, reduced glutathione, nitric oxide, carbonyl proteins) in cardiac tissue and erythrocytessurrogate
Ovarian hormone depletion via ovariectomy exacerbates adriamycin-induced cardiac damage and oxidative stress in experimental animals, suggesting menopause may accelerate pre-existing cardiovascular dysfunctions.
Cite This Study
Muñoz‐Castañeda et al. (2006) studied this question.