What does this research mean for the field?

February 1, 2003Cardiovascular ResearchOpen Access

Estrogen modulation of left ventricular remodeling in the aged heart

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

24 female Sprague-Dawley rats, including aged (~12 months old) intact (n=7), ovariectomized plus placebo (n=7), estrogen-replaced (n=6), and young (~3 months old, n=4)

Intervention

Estrogen replacement for 1 month following ovariectomy

Comparator

Ovariectomized plus placebo, intact aged rats, and young rats

Outcome

Left ventricular weight/body weight ratio (LVW/BW), changes in myosin heavy chain expression (MHC), matrix metalloproteinase (MMP)-2 activity, collagen I/III ratio, and expression of estrogen receptors (ER alpha, ER beta) and Ang II receptors (AT2R, AT1R) in the left ventriclesurrogate

Estrogen replacement attenuates left ventricular remodeling in aged ovariectomized rats, potentially through the regulation of Angiotensin II receptors.

Authors

YXYi XuWuhan University of Technology

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not alter postmenopausal hormone therapy; hypothesis-generating for ERβ/AT1R-mediated remodeling prevention in menopause models.

Cite This Study

Yi Xu (2003) studied this question.

synapsesocial.com/papers/6a17d93bf5abe268d0b41973 https://doi.org/10.1016/s0008-6363(02)00705-8

View Full Paper

Ask AI

Bookmark

Estrogen modulation of left ventricular remodeling in the aged heart

Structured PICO

Discussion

Implication

Cite This Study

Estrogen modulation of left ventricular remodeling in the aged heart

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider