Why the study?
Does estrogen replacement reduce age-associated vascular remodeling and stiffness in aging female rats?
Population
Female Sprague-Dawley rats, 10 months of age (n=12) and 3 months of age (n=6)
Comparison
17beta-estradiol-containing pellet implanted for… vs Placebo pellet implanted for 2 months; young…
Design
Preclinical
Follow-up
2 months
Authors
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Supports estrogen effects on vascular matrix in aged rats; hypothesis-generating for human postmenopausal therapy, requires clinical validation.
Does estrogen replacement reduce age-associated vascular remodeling and stiffness in aging female rats?
Estrogen replacement in aging female rats reduces age-associated vascular remodeling and stiffness, potentially mediated by increased MMP-2 activity.
Zhang et al. (2000) studied this question.
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