Key result
17β-estradiol therapy, whether early or late, preserved diastolic function and cardiac structure in oophorectomized rats, with late supplementation also increasing cardiac nitrite concentrations.
Why the study?
Does 17β-estradiol therapy improve cardiac structure and function in oophorectomized mRen2.Lewis rats?
Population
37 4-week-old female mRen2.Lewis rats (OVX n=24, Sham n=13)
Comparison
17β-estradiol therapy given immediately after… vs Oophorectomized rats without E2 supplementation…
Design
Preclinical, randomized
Authors
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Should not change clinical estrogen therapy; leaves open translation of timing effects on diastolic function from oophorectomized rat models.
RCT (n=37)
Randomized
Does 17β-estradiol therapy improve cardiac structure and function in oophorectomized mRen2.Lewis rats?
In a rat model of estrogen depletion, both early and late 17β-estradiol therapy preserved diastolic function and cardiac structure, with late therapy showing unique benefits on myocardial relaxation and nitric oxide production.
Jessup et al. (2013) conducted an RCT in Oophorectomy-induced hypertension and left ventricular remodeling (n=37). 17β-estradiol (E2) therapy vs. No E2 (OVX) and Sham operation was evaluated on Myocardial function, myocardial structure, and the cardiac nitric oxide system. 17β-estradiol therapy, whether early or late, preserved diastolic function and cardiac structure in oophorectomized rats, with late supplementation also increasing cardiac nitrite concentrations.
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