Key result
One-year hormone replacement therapy significantly reduced epinephrine (P<0.001), norepinephrine, mean blood pressure, and LDL cholesterol (P<0.01), and increased nitrite/nitrate (P<0.01).
Why the study?
Does hormone replacement therapy improve vasoactive biomarkers and oxidative stress in healthy recently postmenopausal women?
RCT (n=15)
Randomized
Does hormone replacement therapy improve vasoactive biomarkers and oxidative stress in healthy recently postmenopausal women?
p-value: p=<0.001
One-year hormone replacement therapy in recently postmenopausal women improved vasoactive biomarkers, blood pressure, and LDL cholesterol without affecting oxidative stress.
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Supports early postmenopausal HRT for vascular biomarker and risk-factor gains; extends RCT data on catecholamines and endothelial markers.
Maffei et al. (2006) conducted an RCT in Healthy recently postmenopausal women (n=15). Hormone replacement therapy (estradiol plus dydrogesterone) vs. Alternative estradiol regimen / Baseline was evaluated on Levels of vasoactive factors and oxidative stress (p=<0.001). One-year hormone replacement therapy significantly reduced epinephrine (P<0.001), norepinephrine, mean blood pressure, and LDL cholesterol (P<0.01), and increased nitrite/nitrate (P<0.01).
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