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November 18, 2025Bioactive MaterialsOpen Access

Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting

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Authors

RZRenjie ZhangWLWei LiJWJiahao Wang

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Overview

Biomimetic nanovesicles enhance corneal penetration and dual-target lens and mitochondria, suggesting improved cataract management.

Key Points

  • To develop an innovative nanodelivery system for cataract treatment that regulates oxidative stress and mitochondrial health.
  • Designed a nanodelivery system (LSPE@Cur) based on cell-penetrating peptides and biomimetic hybrid technology.
  • Utilized curcumin-lipid encapsulation and exosome membrane fusion for efficient delivery.
  • Evaluated the effects on lens epithelial cells and mitochondrial function in vitro and in vivo.
  • LSPE@Cur maintained lens oxidative stress homeostasis effectively.
  • Improved mitochondrial membrane potential was observed.
  • Demonstrated the potential for sustained regulation in cataract treatment through dual-targeting.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6924fee0c0ce034ddc3514dahttps://doi.org/10.1016/j.bioactmat.2025.11.016
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Also Consider

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  1. 1Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities2026
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  3. 3Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment2024 · 22 citations
  4. 4A three-pronged strategy with minimalist nattokinase nanocomposite eye drops breaks the vicious cycle in ultraviolet-B-induced cataract2026
  5. 5A regenerative cerium oxide nanozyme for cataract treatment via oxidative stress regulation2026 · 1 citations