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June 22, 2026Journal of NanobiotechnologyOpen Access

A three-pronged strategy with minimalist nattokinase nanocomposite eye drops breaks the vicious cycle in ultraviolet-B-induced cataract

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Authors

JZJ Y ZhaoJGJian GaoYMYiming Ma

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Overview

Randomized trial shows improvement in cataract symptoms in mice, indicating a new therapeutic approach.

Key Points

  • This research aims to evaluate the therapeutic efficacy of minimalist nattokinase nanocomposites in treating cataracts.
  • Developed minimalist nanocomposites as eye drops via electrostatic self-assembly of nattokinase and natural macromolecules.
  • Conducted in vitro cellular studies to analyze cellular uptake and oxidative stress inhibition.
  • Investigated the effects of nanocomposites on UVB-induced cataract in mice.
  • Nattokinase nanocomposites reduced ROS accumulation by up to 15.78-fold.
  • Effectively suppressed oxidative stress and inflammation in UVB-induced cataracts.
  • Significantly improved lens opacity index, indicating reduced cataract severity.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a38d0a8da1bad9caca30a9fhttps://doi.org/10.1186/s12951-026-04648-z
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