Colloid Adenocarcinoma of the Pancreas Diagnosed after Pancreaticoduodenectomy: A Case Report

Background Colloid adenocarcinoma of the pancreas is a rare malignant epithelial tumour representing 1–3% of pancreatic cancers [1]. It is histologically characterised by abundant extracellular mucin containing sparse neoplastic cells. Case Presentation A 68-year-old male presented with jaundice, pruritus, and weight loss. Laboratory results revealed cholestasis and elevated CA 19-9 (310 U/mL). Contrast-enhanced CT demonstrated a 3.5 cm hypodense lesion in the pancreatic head with biliary and pancreatic duct dilatation, without vascular invasion or metastasis. Pancreaticoduodenectomy was performed. Histopathology revealed mucin pools with cribriform and tubular clusters of atypical epithelial cells consistent with colloid adenocarcinoma. Immunohistochemistry was positive for CK7 and MUC2, focally CDX2, and negative for MUC1 [7, 10]. Resection margins and all 17 lymph nodes were free of tumour. The postoperative course was uneventful, and the patient remained disease-free at 12 months. Conclusion Colloid adenocarcinoma is a rare pancreatic tumour with distinctive histological and immunohistochemical features, often associated with IPMN. Recognition of this entity is essential due to its relatively favourable prognosis compared with ductal adenocarcinoma [4, 5].