Research shows type I interferon improves tissue regeneration in salivary glands, suggesting proton irradiation enhances this effect.
Innate immune signaling is important for tissue regeneration. In this issue of Science Signaling , Cinat et al . report that a cell-intrinsic type I interferon (IFN-I) response drives salivary gland organoid regeneration after radiation and that proton irradiation induces a stronger regenerative response than photon irradiation because it amplifies the IFN-I response.
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