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November 18, 2025Diabetes Obesity and MetabolismOpen Access

Effects of hypoxic training interventions on cardiometabolic health of adults with overweight and obesity: A systematic review and meta‐analysis

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Authors

AGAlessandro GattiCCCaterina CavalloMGMatteo Giuriato

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Overview

Systematic review compares hypoxic and normoxic training effects on glucose, lipid profiles, and blood pressure in obese adults, suggesting no significant differences.

Key Points

  • Evaluate the effectiveness of hypoxic training compared to normoxic training on cardiometabolic health in adults with overweight and obesity.
  • Conducted a systematic review and meta-analysis of randomised controlled trials
  • Included trials focusing on hypoxic vs normoxic training in adults with overweight or obesity
  • Assessed outcomes including glucose homeostasis, lipid profile, and blood pressure
  • Performed subgroup, moderation, and sensitivity analyses to explore findings' heterogeneity
  • Meta-analysis showed no significant differences in fasting glucose (p = 0.118) and fasting insulin (p = 0.415) between training types
  • Lipid profile and blood pressure outcomes also revealed no significant between-group differences (all p > 0.05)
  • Substantial heterogeneity was observed across studies (I2 = 60%–77%)
  • Shorter and lower-intensity hypoxic interventions suggested to be more effective for fasting glucose reductions

Cite This Study

Gatti et al. (2025) studied this question.

synapsesocial.com/papers/6924fee6c0ce034ddc351807https://doi.org/10.1111/dom.70303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Aerobic Exercise Training in Hypoxia Versus Normoxia on Body Composition and Metabolic Health in Overweight and/or Obese Populations: an Updated Meta-Analysis2025
  2. 2The Impact of Exercise Training in a Hypobaric/Normobaric Hypoxic Environment on Cardiometabolic Health in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis2025 · 5 citations
  3. 3Effect of Hypoxic Exercise with Different Oxygen Concentrations on Metabolic Outcomes in Obesity: A Systematic Review and Network Meta-Analysis2026
  4. 4Effectiveness of hypoxic versus normoxic exercise on cardiovascular function in people without cardiovascular diseases: A systematic review and meta‐analysis2025 · 1 citations
  5. 5The effects of hypoxic versus normoxic exercise training on body composition, cardiometabolic health markers, and functional performance in adults: a systematic review and meta-analysis2026