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November 18, 2025Frontiers in ImmunologyOpen Access

Reprogramming the tumor microenvironment to overcome immunotherapy resistance in pancreatic cancer

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Authors

XHXianfeng HuiXHXianfeng HuiXHXianfeng Hui

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Overview

Review demonstrates therapeutic strategies to improve immune response in pancreatic cancer by targeting tumor microenvironment factors.

Key Points

  • This review examines the mechanisms of immune evasion in pancreatic cancer's tumor microenvironment and therapeutic interventions.
  • Analysis of the cellular, stromal, and metabolic aspects of the pancreatic cancer tumor microenvironment.
  • Evaluation of recent studies and emerging technologies for tumor microenvironment reprogramming.
  • Immunosuppressive factors like myeloid-derived suppressor cells and tumor-associated macrophages impair immune activation.
  • Strategies like extracellular matrix remodeling and metabolic reprogramming show potential in enhancing immunotherapy effectiveness.

Cite This Study

Hui et al. (2025) studied this question.

synapsesocial.com/papers/6924fef4c0ce034ddc351d12https://doi.org/10.3389/fimmu.2025.1717062
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  1. 1Research progress on the influence of tumor microenvironment on immunotherapy for pancreatic ductal adenocarcinoma2026
  2. 2Targeting the Tumour Microenvironment in Pancreatic Cancer: From Stromal Reprogramming to Emerging Therapeutics2026 · 1 citations
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  4. 4Immune Evasion in Pancreatic Ductal Adenocarcinoma: Mechanistic Insights and Emerging Strategies to Reinvigorate Anti-Cancer Immunity2026
  5. 5Targeted Therapy for Highly Desmoplastic and Immunosuppressive Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma2024 · 27 citations