Selective Construction of Diverse Polycyclic Compounds by Electrophilic Cyclizations of Biaryl-Embedded 1,7-Enynes

Electrophilic cyclizations of biaryl-embedded 1,7-enynes enable the selective synthesis of dibenzofused polycycles with diverse topologies. The outcome strongly depends on the promoter—gold(I) complexes, Brønsted acids, or electrophilic boron reagents—as well as the substitution pattern of the enyne. This Account highlights recent advances and establishes a basis for future developments through the controlled design of substrates and activation modes.